NFL Week 10 Betting Previews, Picks & Predictions

The action once again starts on Thursday night, and there are games all the way through Monday. Here is a look at all of the Week 10 matchups, with a NFL betting pick and prediction for each game included. 

The second half of the NFL season is set to get underway this weekend as there is a loaded Week 10 NFL Football slate. Not only are you going to see some great matchups taking place throughout the weekend, but there are also some good betting options throughout the weekend. 

The action once again starts on Thursday night, and there are games all the way through Monday. Here is a look at all of the Week 10 matchups, with a NFL betting pick and prediction for each game included. 

Carolina Panthers vs. Chicago Bears

Two of the worst teams in the NFL are set to battle it out on Thursday Night Football as the Carolina Panthers visit the Chicago Bears. Carolina has won just one game so far this season, and the Bears aren’t much better at 2-7.

There is a ton on the line in this game, but the Chicago Bears are going to be going with rookie Tyson Bagent at quarterback again in this game. Even though it’s been a rough season for the Bears, look for them to win this game and cover 3.5 point spread to win. 

Indianapolis Colts vs. New England Patriots

The 4-5 Indianapolis Colts will take on the 2-7 New England Patriots in Frankfurt this weekend as the NFL returns to Germany. Indianapolis is a slim 1.5-point betting favorite in this game, but neither team is having a good season. 

New England just continues to struggle to score points this season, but this game will be won on defense. Indianapolis just doesn’t do enough things well to pull ahead, and the Patriots get an upset win in this game. 

Houston Texans vs. Cincinnati Bengals

The Houston Texans have been a major surprise this season as they are sitting at 4-4 on the year. Houston has a tough challenge ahead in this game though as they are on the road to face the 5-3 Cincinnati Bengals. 

There is a reason that the Bengals are seven-point betting favorites this weekend, but this should be a battle. The Bengals are going to survive and win a game this weekend, but taking the points is the way to go. 

Green Bay Packers vs. Pittsburgh Steelers

The Green Bay Packers are having a rough season at 3-5 through eight games, and Jordan Love has struggled at quarterback. Green Bay did pick up a win last weekend, but they are on the road in Pittsburgh in Week 10. 

This Steelers team is sitting at 5-3 on the year, and they have found a way to be successful this season. There is a slim 3.5-point betting spread in this matchup, and Pittsburgh will find a way to win and cover this small of a spread. 

Tennessee Titans vs. Tampa Bay Buccaneers

A pair of 3-5 teams are set to meet up in Tampa Bay on Sunday as the Buccaneers will host the Tennessee Titans. Both teams are probably better than their records suggest, but they just haven’t been able to win games. 

Tennessee has turned to Will Levis at the quarterback position for the rest of the year, and that’s going to allow this offense to take off. Even though the Buccaneers are slight favorites in this game, Tennessee is going to come up with a win. 

Cleveland Browns vs. Baltimore Ravens

The Baltimore Ravens are now at the top of the AFC at 7-2, and they come into Week 10 with a ton of momentum. Cleveland was supposed to battle with the Ravens in this division, but the Browns are sitting at 5-3.

This Ravens team just keeps getting better on offense, and they have also been great at getting stops. Cleveland will keep this game tight for three quarters, but ultimately the Ravens are going to win this game and cover the 6.0-point betting spread. 

San Francisco 49ers vs. Jacksonville Jaguars

Two of the best teams in the NFL are going to meet up this weekend in Jacksonville, and the 49ers are actually three-point betting favorites. San Francisco has dropped three games in a row, and injuries have been a major part of the recent struggles. 

Jacksonville comes into this game with a ton of momentum, and this team is showing absolutely no signs of slowing down. The Jaguars are three point underdogs in this game, but they are going to win this game at home to move to 7-2. 

New Orleans Saints vs. Minnesota Vikings

A pair of 5-4 teams will meet in Minnesota this weekend as the Vikings are set to host the New Orleans Saints. Minnesota has won two games in a row, while Minnesota has rattled off four straight wins. 

The Saints are favorites in this game, and it makes sense as the Vikings are playing without quarterback Kirk Cousins. This should be a good battle, but New Orleans is going to have what it takes to get the job done and cover the spread in this one. 

Atlanta Falcons vs. Arizona Cardinals

In one of the most surprising spreads of Week 10, the Atlanta Falcons are only 1.5-point betting favorites on the road at Arizona. The Cardinals have won just one game this season, but they could be getting their starting quarterback on the field in this one. 

Even if Kyler Murray is set to return, it’s hard to see the Cardinals finding a way to play well enough to win. This betting spread just hasn’t felt right since it was released as Atlanta is winning this game by a touchdown. 

Detroit Lions vs. Los Angeles Chargers

If you are looking for points then you are going to want to look at the matchup between the Detroit Lions and Los Angeles Chargers. Detroit is coming into this game at 6-2, while Los Angeles has gone just 4-4 to begin the year. 

The Lions are three-point betting favorites on the road in this game, but it’s hard to ignore what the Chargers have done of late. Going with Los Angeles to win this game at home is the right way to go. 

New York Giants vs. Dallas Cowboys

NFC East rivals meet up on Sunday in what has the biggest spread of the weekend. The Dallas Cowboys are 16-point betting favorites over the New York Giants, and this game is not going to be close. 

Dallas is one of the best teams in the league this season, and New York is now playing without it’s starting quarterback. This game is going to be over by halftime as the Cowboys roll to a 20-point victory in Week 10. 

Washington Commanders vs. Seattle Seahawks

The Seattle Seahawks are 6.5-point betting favorites as they host the Washington Commanders in Week 10. Washington is still in the playoff  hunt at 4-5 on the year, but they still have some serious work left to do. 

Seattle really struggled in a Week 9 loss to the Baltimore Ravens, but they have been a great team all season long. This is a chance to get back on track as the Seahawks are going to win this game and also cover the spread. 

New York Jets vs. Las Vegas Raiders

The Sunday Night Football matchup in Week 10 is intriguing as the New York Jets visit the Las Vegas Raiders. This game is basically a pick’em and it’s a battle of two teams that are hard to figure out. 

New York saw their three game losing streak end last weekend in a blowout loss, and this offense just can’t seem to find any success. Las Vegas has a new outlook on the season with a new head coach, and they are going to win this game and cover the spread. 

Denver Broncos vs. Buffalo Bills

The Monday Night Football matchup in Week 10 is a battle between AFC teams that are struggling a bit. The 3-5 Denver Broncos visit the 5-4 Buffalo Bills, and the home team is a 7.5-point favorite. 

Denver has been a disaster on defense this season, and that is where things are going to get out of control in this game. Buffalo will light up the scoreboard on Monday Night Football as the Bills will roll to a major win. 

There you have it! Make sure to check out our top regulated sportsbooks list to find your best place to bet on Week 10.