NFL Week 12 Betting Previews, Picks & Predictions

Week 12 of the NFL season always seems to be when things really start to crank up, and that should be the case this year as well.

Week 12 of the NFL season always seems to be when things really start to crank up, and that should be the case this year as well. The NFL action is going to begin with three games on Thanksgiving Day, and the games are going to continue all the way until Monday. 

Here is a look at all of the NFL Week 12 matchups and a betting pick and prediction for each game. 

Green Bay Packers vs. Detroit Lions

NFC North rivals are going to kick the Week 12 action off in Detroit as the Lions will host the Green Bay Packers. Detroit has won four straight games in this head-to-head matchup, and they are pretty big betting favorites this season as well. 

Green Bay has struggled on offense with Jordan Love at quarterback, and that defense is going to have its hands full in this game. Look for the Lions to have a big game at home on Thanksgiving as they win and cover the 7.5-point spread. 

Washington Commanders vs. Dallas Cowboys

There will be another rivalry game on Thursday afternoon as the Dallas Cowboys host the Washington Commanders. This matchup has produced some classic games throughout the year, but don’t expect to see that this time around. 

Washington has not been a good offensive team at all this season, and Dallas can put points on the board in a hurry. Bet the Dallas Cowboys -13.5 as they are going to roll to their eighth win of the season. 

San Francisco 49ers vs. Seattle Seahawks

The final game on Thanksgiving Day will be an interesting one as the San Francisco 49ers will visit the Seattle Seahawks. This Seahawks team is always tough to deal with in San Francisco, but there is a reason that the 49ers are big favorites. 

Don’t expect this game to be a blowout at all, and the Seahawks are good enough to keep it interesting. It’s not going to matter in the end though as San Francisco is going to win this game by double-digits to cover the spread. 

Miami Dolphins vs. New York Jets

The New York Jets are going to try to get back on track as they host the Miami Dolphins on Friday afternoon. This Jets team has been the worst offensive team in the league this season, and the defense continues to try and do everything.

Miami hasn’t been as dominant of late as they were to begin the year, but the offensive numbers are still ridiculous to look at. The Dolphins won’t be able to cover the 9.5-point spread in this game, but they will still pick up a solid road victory. 

Pittsburgh Steelers vs. Cincinnati Bengals

AFC North rivals will meet up in Cincinnati on Sunday afternoon as the 5-5 Bengals will host the 6-4 Pittsburgh Steelers. Joe Burrow is out for the rest of the season for the Bengals, and the Pittsburgh Steelers have struggled to score all season long. 

It’s going to come down to which team is able to hit on some big plays, and it’s hard to trust the Steelers to get that done. Cincinnati is an underdog at home in this game, but they are going to pick up a monster victory. 

Jacksonville Jaguars vs. Houston Texans

First place in the AFC South is on the line when the Jacksonville Jaguars visit the Houston Texans. Jacksonville has won four of their last five games, while Houston has rattled off three straight wins in dramatic fashion. 

The Jaguars are a hard team to figure out, and they have definitely had some issues throughout the year. Look for the offense of Houston to be the difference in this one as C.J. Stroud will lead his team to another upset win. 

Tampa Bay Buccaneers vs. Indianapolis Colts

The Tampa Bay Buccaneers are trying to get back on track as they visit the Indianapolis Colts as slim underdogs. Tampa Bay just hasn’t gotten enough from quarterback Baker Mayfield and the defense has started to scuffle a bit.

Indianapolis hasn’t been a good offensive team either, but they still have a star running back on their roster. The Colts will be able to pick up yards on the ground when needed, and that will allow them to win this game by at least three points. 

New Orleans Saints vs. Atlanta Falcons

The NFC South has been terrible this season, but the top two teams are going to square off this weekend. The New Orleans Saints will try to hand the Atlanta Falcons their fourth straight loss, and the home team is going back to a young quarterback.

The difference in this game should be running back Alvin Kamara as he will have a big game for New Orleans. This will be a back-and-forth battle on Sunday, but the Saints are going to pick up a small upset win. 

New England Patriots vs. New York Giants

Two of the worst teams in the league are battling it out in New York as the Giants are hosting the New England Patriots. This game will have huge implications on the 2024 NFL Draft order, but both teams will also be trying to win. 

The Patriots are 3.5-point betting favorites in this game, and this is the type of game that head coach Bill Belichick thrives in. New York is going to struggle to do much on offense as the Patriots win and cover the spread. 

Carolina Panthers vs. Tennessee Titans

The Carolina Panthers are going to be looking for win number two on the season when they visit the Tennessee Titans this weekend. Carolina rookie quarterback Bryce Young has had some decent games this season, but he has also struggled at times. 

Tennessee continues to search for a quarterback, but running back Derrick Henry has been the difference this season. This Titans team is going to feed Henry a ton in this game, and he will help the home team cover the 3.5-point spread in this game. 

Los Angeles Rams vs. Arizona Cardinals

The Los Angeles Rams have really struggled since winning the Super Bowl, and they are now just 1.5-point betting favorites on the road against the 2-8 Arizona Cardinals. Arizona has been more competitive now that Kyler Murray is back and playing, but they still have some flaws. 

Los Angeles is still a team that can put points on the board in a hurry, and they are going to find a way to be aggressive in this one. Arizona can keep it close for awhile, but ultimately it will be the Rams that take control and win this game. 

Cleveland Browns vs. Denver Broncos

The Cleveland Browns are now playing without quarterback Deshaun Watson for the rest of the season, and that is going to hurt this offense. Cleveland has been winning games with defense this season, and they will try to shut down the Denver Broncos on Sunday. 

This Broncos team has now rattled off four wins in a row, but they have been barely surviving in those wins. Look for that run to come to an end in this game, and taking the Browns to pull off an upset as a slight underdog is the way to go. 

Kansas City Chiefs vs. Las Vegas Raiders

The Kansas City Chiefs are coming off of a loss to the Philadelphia Eagles at home, and they now have a tough road trip ahead of them. Kansas City will be in Las Vegas to face the Raiders, and that team has started to turn things around. 

Patrick Mahomes and the Chiefs don’t tend to struggle for long, and they always seem to find a way to get back on track in a hurry. Kansas City is a big 8.5-point betting favorite for a reason, and they will win this game by double-digits. 

Buffalo Bills vs. Philadelphia Eagles

The Philadelphia Eagles just continue to do what is needed to win games, and they are an NFL-best 9-1 on the year. Philadelphia will now return home to face the 6-5 Buffalo Bills, and that team can’t seem to get anything going. 

This should be a game in which both teams are able to make some big plays, and that will keep things close throughout the four quarters. Take the 3.5 points and back the Bills as they will battle, but the Eagles are going to move to 10-1. 

Baltimore Ravens vs. Los Angeles Chargers

The Los Angeles Chargers are going to try to save their season on Sunday as they are in danger of falling to 4-7. Los Angeles is a 3.5-point betting underdog to the Baltimore Ravens, and Baltimore appears to be on a roll. 

That Ravens offense has been putting up some huge numbers this season, and that is going to be the difference in this game. Los Angeles just won’t be able to get any stops in this one, and the Ravens will win and cover the spread on the road. 

Chicago Bulls vs. Minnesota Vikings

The final game of the weekend will feature the Chicago Bears and Minnesota Vikings squaring off on Monday Night Football. Minnesota won the first game between these two teams, but the Vikings have been hit hard by the injury bug this season. 

Nothing seems to be going right for the Bears, but quarterback Justin Fields can still make some big plays on offense. Taking the 3.5-points and backing the Bears is the way to go, but the Vikings should survive and win the game.

Reminder you can make your bets at one of the legal US sportsbooks in your area. Enjoy the big week of football.